PSMA-617 free base
Description
PSMA-617, also know as vipivotide tetraxetan. It is a ligand used to make 177Lu-PSMA-617, which is a radioactive molecule to fight cancer. PSMA617 possesses a small peptide, which was designed to target prostate-specific membrane antigen (PSMA). PSMA617 demonstrates high radiolytic stability for at least 72 h. PSMA617 has high inhibition potency (equilibrium dissociation constant Ki=2.34±2.94 nM on LNCaP; Ki=0.37±0.21 nM enzymatically determined). 177 Lu-PSMA-617 offers a potential additional life-prolonging treatment option for men with mCRPC.
Theoretical Analysis
- Name: PSMA-617 free base
- CAS#: 1702967-37-0 (free base)
- Chemical Formula: C49H71N9O16
- Exact Mass: 1041.5019
- Molecular Weight: 1042.15
- Elemental Analysis: C, 56.47; H, 6.87; N, 12.10; O, 24.56
PSMA-617 TFA
Description:
PSMA-617 (vipivotide tetraxetan) is a small-molecule ligand targeting prostate-specific membrane antigen (PSMA), developed as a radioligand therapy vector. PSMA-617 (vipivotide tetraxetan) shows high, specific bioactivity against prostate-specific membrane antigen (PSMA). In vitro, PSMA-617 binds human PSMA with low-nanomolar affinity (Kd ~1–2 nM) and is rapidly internalized in PSMA-positive prostate cancer cells (e.g., LNCaP), while showing minimal binding to PSMA-negative cells. When radiolabeled (e.g., with ^177Lu), it delivers potent, PSMA-dependent cytotoxicity via localized β-radiation. In vivo, mouse xenograft models bearing PSMA-positive tumors demonstrate high and sustained tumor uptake (often >10–15 %ID/g at 24 h), favorable tumor-to-blood and tumor-to-muscle ratios, and significant tumor growth inhibition or regression after therapeutic dosing. Non-target uptake is mainly renal, consistent with clearance pathways, supporting a strong therapeutic index in PSMA-expressing tumors
Theoretical Analysis
- Name: PSMA-617 TFA
- CAS#: PSMA617 TFA
- Chemical Formula: C57H75F12N9O24
- Exact Mass: 0.0000
- Molecular Weight: 1498.25
- Elemental Analysis: C, 45.70; H, 5.05; F, 15.22; N, 8.41; O, 25.63
FAPI-2
Description:
FAPI-2 is a Quinoline-Based Theranostic Ligands for the Targeting of Fibroblast Activation Protein. FAPI-2 is a ligand to make 68Ga-FAPI-2, which is a PET tracer that act as FAP inhibitor (FAPI). 68Ga-FAPI-2 demonstrated promising result. FAPI PET/CT is a new diagnostic method in imaging cancer patients. In contrast to 18F-FDG, no diet or fasting in prepn. for the examn. is necessary, and image acquisition can potentially be started a few minutes after tracer application. Tumor-to-background contrast ratios were equal to or even better than those of 18F-FDG.
Theoretical Analysis
- Name: FAPI-2
- CAS#: 2370952-98-8
- Chemical Formula: C40H56N10O10
- Exact Mass: 836.4181
- Molecular Weight: 836.95
- Elemental Analysis: C, 57.40; H, 6.74; N, 16.74; O, 19.12
DOTA-TATE
Description:
DOTA-TATE can be reacted with the radionuclides gallium-68 (T1/2 = 68 min), lutetium-177 (T1/2 = 6.65 d) and copper-64 (T1/2 = 12.7 h) to form radiopharmaceuticals for positron emission tomography (PET) imaging or radionuclide therapy. DOTA-TATE is a compound containing tyrosine3-octreotate, an SSR agonist, and the bifunctional chelator DOTA (tetraxetan). SSRs are found with high density in numerous malignancies, including CNS, breast, lung, and lymphatics.
Theoretical Analysis
- Name: DOTA-TATE
- CAS#: 177943-88-3 (free base)
- Chemical Formula: C65H90N14O19S2
- Exact Mass: 1434.5900
- Molecular Weight: 1435.63
- Elemental Analysis: C, 54.38; H, 6.32; N, 13.66; O, 21.17; S, 4.47
Ferrostatin-1
Description:
Ferrostatin-1 (Fer-1) is a lipophilic antioxidant that effectively blocks ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. Fer-1 inhibited the ROS/RNS generated under rotenone insult in SH-SY5Y cells. Fourth, we revealed the effective role of Fer-1 in ER stress mediated activation of apoptotic pathway. Finally, we reported that Fer-1 mitigated rotenone-induced α-syn aggregation.
Theoretical Analysis
- Name: Ferrostatin-1
- CAS#: 347174-05-4
- Chemical Formula: C15H22N2O2
- Exact Mass: 262.1681
- Molecular Weight: 262.35
- Elemental Analysis: C, 68.67; H, 8.45; N, 10.68; O, 12.20